陶庆华 博士
教授
1988-1992 四川大学生物工程系遗传学专业 学士
1995-2000 中科院上海细胞所发育生物学专业 博士
2000-2008 美国俄亥俄州辛辛那提市儿童医院发育生物学系博士后，研究助理
2008 至今 澳门尼斯人娱乐网站(中国)有限公司 教授
● 研究兴趣、领域：
研究领域：本实验室综合运用基因组学、蛋白质组学、分子生物学、遗传学等技术，研究脊椎胚胎早期发育中的细胞命运决定和分化的分子机理，尤其是储备在卵母细胞中的mRNA、蛋白、小分子等母源因子的作用。
研究方向：
1、Wnt/b-catenin信号在Spemann组织者生成中的作用与调控机理
2、母源背方决定因子Huluwa与Wnt信号的互作机理
3、母源因子在胚胎细胞神经命运决定和分化中的作用
● 代表性论文：
1. Yan L#, Chen J#, Zhu XC#, Sun JW, Wu XT, Shen WM, Zhang WY, Tao QH* , Meng AM* (2018) Maternal Huluwa Dictates the Embryonic Body Axis through b-catenin in Vertebrates. Science 362(6417). pii: eaat1045. doi: 10.1126/science.aat1045. (* Co-correspondence authors).
2. Lin H1#, Zhu XC1#, Chen G1, Song L1, Gao L1, Khand AA1, Chen Y2, Lin GF2*, Tao QH1* (2017) KDM3A-mediated dimethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis. Development 144(20): 3674-3685. (*Correspondence author).
3. Li YB, Zhao D, Horie T, Chen G, Bao HC, Chen SY, Liu WH, Horie R, Liang T, Dong BY, Feng QQ, Tao QH, and Liu X (2017) Conserved gene regulatory module specifies lateral neural borders across bilaterians. Proc Natl Acad Sci USA. 114(31): E6352-E6360. doi: 10.1073/pnas.1704194114.
4. Wang L, Liu Z, Lin H, Ma D, Tao QH, Liu F (2017) Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 36(20):2987-2997. doi: 10.15252/embj. 201796580.
5. Gao L, Zhu XC, Chen G, Ma X, Zhang Y, Khand A, Shi H, Gu F, Lin H, Chen Y, Zhang H, He L, Tao QH* (2016) A novel role for Ascl1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT function. Development 143(3):492-503. (*Correspondence author).
6. Lin H, Min Z, Tao QH* (2016) The MLL/Setd1b methyltransferase is required for the Spemann’s organizer gene activation in Xenopus. Mech. Dev. 142:1-9.
7. Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen YG, Zhang MQ*, Tao QH* , Wu W* (2015) Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos. J. Biol. Chem. 290(28):17239-49. (* co-correspondence authors).
8. Zhang Y, Ding Y, Chen YG*, Tao QH* (2014) NEDD4L regulates convergent extension movements in Xenopus embryos via Dishevelled-mediated non-canonical Wnt signaling. Dev. Biol. 392(2014): 15-25. (* Co-correspondence authors).
9. Ding Y, Zhang Y, Xu C, Tao QH* and Chen YG* (2013) HECT Domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting Dishevelled for proteasomal degradation. J. Biol. Chem. 288, 8289-98. (* Co-correspondence authors).
10. Tao QH, Yokota C, Puck H, Kofron M, Birsoy B, Dong Y, Asashima M, Wylie C, Lin X and Heasman J. (2005a). Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120:857-871.
● 联系方式：
电话：86-10-62788745
Email: qhtaolab@mail.tsinghua.edu.cn
