郗乔然 博士

副教授

1989-1993年，南京大学生物化学系　　　　　学士

1998-2004年，美国纽约大学医学院　　　　　生物医学博士

2004-2005年，美国纽约大学医学院　　　　　博士后

2006-2013年，美国斯隆凯特琳癌症研究中心　博士后

2013年至今，  澳门尼斯人娱乐网站(中国)有限公司　　　　助理教授、副教授

●  研究兴趣、领域：

本课题组的学术研究主要是运用细胞生物学，生物化学，分子生物学，基因组学等方法研究TGF-beta信号传导在胚胎干细胞的自我更新和胚胎发育及癌症发生过程中的作用机制；针对性研究TGF-beta及相关信号传导通路如何通过与表观遗传图谱相互作用，在时间和空间上紧密调控基因表达从而调控胚胎发育及癌症发生。本课题组的研究对象是小鼠胚胎干细胞和弥漫内生型脑干胶质瘤（DIPG）。

●  开设的课程：

分子生物学（英）、生命科学交叉创新挑战性问题研讨课（X-idea）、科研训练（H）

●  代表性论文：

1. Kong X, Yan K, Deng P, Fu H, Sun H, Huang W, Jiang S, Dai J, Zhang Q, Liu J and Xi Q*. (2022) LncRNA-Smad7 mediates cross-talk between Nodal/TGF- and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells. Nucleic Acids Research. https://doi.org/10.1093/nar/gkac780.

2. Sun Y^#, Yan K^#, Wang Y^#, Xu C^#, Wang D, Zhou W, Guo S, Han Y, Tang L, Shao Y, Shan S, Zhang Q, Tang Y, Zhang L*, Xi Q*. (2022) Context-dependent tumor suppressive BMP signaling in Diffuse Intrinsic Pontine Glioma regulates stemness through epigenetic regulation of CXXC5. Nature Cancer. 3: 1105-1123.

3. Liang T^#, Bai J^#, Zhou W, Lin H, Ma S, Zhu X, Tao Q, Xi Q*. (2022) HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs. Cell Reports. 40(2):111038.

4. Fu H, Wang T, Kong X, Yan K, Yang Y, Cao J, Yuan Y, Wang N, Kee K, Lu Z, Xi Q*. (2022) A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells. Nature Communications. 13: 3984.

5. Zuo F^#, Jiang J^#, Fu H^#, Yan K, Liefke R, Zhang J, Hong Y, Chang Z, Liu N, Wang Z*, Xi Q*. (2022) A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells. Cell Stem Cell. 29(6), 948-961.

6. Luo M, Bai J^#, Liu B^#, Yan P^#, Zuo F, Sun H, Sun Y, Xu X, Song Z, Yang Y, Massagué J, Lan X, Lu Z, Chen YG, Deng H, Xie W, and Xi Q*. (2019) H3K18ac primes mesendodermal differentiation upon nodal signaling. Stem Cell Reports.13(4): 642-656.

7. Sun Y^#, Sun Y^#, Yan K, Li Z, Xu C, Geng Y, Pan C, Chen X, Zhang l*, Xi Q*. (2019) Potent anti-tumor efficacy of palbociclib in H3.3K27M-mutant diffuse intrinsic pontine glioma. EBioMedicine. 43:171-179.

8. Tian W^#, Yan P^#, Xu N, Chakravorty A, Liefke R*, Xi Q* and Wang Z*. (2019) The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin. Nucleic Acids Research. 47(10): 5436-5448.

9. Bai J, Xi Q*. (2018) Crosstalk between TGF-β signaling and epigenome. Acta Biochimica Biophys Sin. 50(1): 60-67. (Review)

10. Xia X, Zuo F, Luo M, Sun Y, Bai J, Xi Q*. (2017) Role of TRIM33 in Wnt signaling during mesendoderm differentiation. Sci China Life Sci. 60(10): 1142-1149.

11. Massagué J, and Xi Q. (2012) TGF-β control of stem cell differentiation genes. FEBS Letters 586: 1953-8. (Review)

12. Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang L, Liu JX, Kim H, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, and Massagué J*. (2011) A poised chromatin platform for TGFβ access to master regulators. Cell 147: 1511-24.

13. Xi Q, He W, Zhang XH, Le HV, Massagué J*. (2008) Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor β transcriptional program. J Biol Chem. 283: 1146-55.

14. Xi Q, Cuesta R, and Schneider RJ*. (2005) Regulation of ribosome shunting translation by phosphotyrosine-dependent coupling of adenovirus 100k protein to viral mRNAs. J. Virol. 79: 5676-5683.

15. Xi Q, Cuesta R, and Schneider RJ*. (2004) Tethering of eIF4G to Adenoviral 100k protein drives ribosome shunting. Genes Dev. 18: 1997- 2009.

 

●  联系方式：

电话：+86-10-62789636（实验室）

公众号：

E-mail：xiqiaoran@mail.tsinghua.edu.cn

通讯地址：公司郑裕彤医学楼E103