王一国 博士

副教授

1997.9－2001.7       曲阜师范大学澳门尼斯人娱乐网站 学士

2001.9－2007.1       中科院上海生物化学与细胞生物学研究所     博士

2007.8－2012.8       美国索儿克研究所   博士后

2012.8－            澳门尼斯人娱乐网站(中国)有限公司  副教授

●  研究兴趣、领域：

能量稳态的激素信号调控：1）经典激素调控能量稳态的新的分子机制；2）高等生物特有的新的激素及其对能量稳态的调控；3）新的调控机制在糖尿病及肿瘤等代谢性疾病中的作用。

●  代表性论文：

1. Yi Liu#, Yuanyuan Zhang#, Tong Li, Jinbo Han and Yiguo Wang*. (2020) The tight-junction protein TJP1 regulates the feeding-modulated hepatic circadian clock. Nat Commun. 11(1), 589.
2. Erwei Li#, Haili Shan#, Liqun Chen#, Aijun Long#, Yuanyuan Zhang#, Yang Liu, Liangjie Jia, Fangchao Wei, Jinbo Han, Tong Li, Xiaohui Liu, Haiteng Deng and Yiguo Wang*. (2019) OLFR734 mediates glucose metabolism as a receptor of Asprosin. Cell Metab. 30, 319-328.
3. Liqun Chen#, Ke Wang#, Aijun Long, Liangjie Jia, Yuanyuan Zhang, Haiteng Deng, Yu Li, Jinbo Han and Yiguo Wang*. (2017) Fasting-induced hormonal regulation of lysosomal function. Cell Res. 27, 748-763.
4. Jinbo Han#, Erwei Li#, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng and Yiguo Wang*. (2015). The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524, 243-246.
5. Yiguo Wang, Gang Li, Jason Goode, Jose C. Paz, Kunfu Ouyang, Robert Screaton, Wolfgang H. Fischer, Ju Chen, Ira Tabas and Marc Montminy*. (2012). InsP3 receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485, 128-132.
6. Yiguo Wang, Hiroshi Inoue, Kim Ravnskjaer, Kristin Viste, Nina Miller, Yi Liu, Susan Hedrick, Liliana Vera, and Marc Montminy*. (2010). Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. 107, 3087-3092.
7. Yiguo Wang, Liliana Vera, Wolfgang H Fischer, Marc Montminy*. (2009). The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537.
8. Yiguo Wang, Dan Du, Longhou Fang, Guang Yang, Chenyi Zhang, Rong Zeng, Axel Ullrich, Friedrich Lottspeich, Zhengjun Chen*.  Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.  The EMBO Journal. (2006) 25, 5058-5070.

●  联系方式：

电话：+86-10-62783209

E-mail: yiguo@mail.tsinghua.edu.cn