陈浩东 博士
助理教授
1999 – 2003 北京大学澳门尼斯人娱乐网站 学士
2003 – 2008 北京大学澳门尼斯人娱乐网站 博士
2006 – 2008 耶鲁大学分子细胞与发育生物学系 交换学生
2008 – 2010 北京大学澳门尼斯人娱乐网站/化学学院 博士后
2010 – 2020 北京大学澳门尼斯人娱乐网站 副研究员
2020 – 至今 澳门尼斯人娱乐网站(中国)有限公司 助理教授
2020 – 至今 公司-北大生命科学联合中心 研究员
● 研究兴趣、领域：
作为地球上持续存在的核心物理环境因子，重力在调控植物的生长方向与形态等方面发挥重要作用，然而重力的物理信息如何转变为植物体内的生理信号却是“百年未解之谜”。本实验室综合运用小立碗藓、拟南芥、水稻等模式植物，探索植物中重力感受与信号传递的机制，具体研究：（1）植物感受重力的机制；（2）植物中向重力性方向决定的机制;（3）植物的向性改良。这些研究将为地球上作物的性状改良乃至太空微重力环境下的作物培育提供知识基础。
● 代表性论文：
1. Li, Y., Deng, Z., Kamisugi, Y., Chen, Z., Wang, J., Han, X., Wei, Y., He, H., Terzaghi, W., Cove, D.J., Cuming, A.C., Chen, H.* (2021). A minus-end directed kinesin motor directs gravitropism in Physcomitrella patens. Nat Commun 12, 4470.
2 Wang, X., Yu, R., Wang, J., Lin, Z., Deng, Z., He, H., Fan, L., Deng, X.W., and Chen, H.*(2020). The asymmetric expression of SAUR genes mediated by ARF7/19 promotes the gravitropism and phototropism of plant hypocotyls. Cell Rep, 31, 107529.
3. Yang, P., Wen, Q., Yu, R., Han, X., Deng, X.W.*, and Chen, H.* (2020) .Light modulates the gravitropic responses through organ-specific PIFs and HY5 regulation of LAZY4 expression in Arabidopsis. Proc Natl Acad Sci U S A117, 18840-18848.
4. Dong, J., Sun, N., Yang, J., Deng, Z., Lan, J., Qin, G., He, H., Deng, X.W., Irish V.F., Chen, H.* and Wei, N.* (2019) .TCP4 and PIF3 antagonistically regulate organ-specific light induction of SAUR16/50 to modulate cotyledon opening during de-etiolation in Arabidopsis. Plant Cell31, 1155-1170.
5. Dong, J., Ni, W., Yu, R., Deng, X.W.,Chen, H.* and Wei, N. (2017). Light-dependent degradation of PIF3 by SCFEBF1/2 promotes a photomorphogenic response in Arabidopsis. Curr Biol 27, 2420-2430. Highlighted by “news & views” of Nat Plants 3, 846–847 (2017)
6. Sun, N., Wang, J., Gao, Z., Dong, J., He, H., Terzaghi, W., Wei, N., Deng, X.W.,* and Chen, H.*(2016). Arabidopsis SAURs are critical for differential light regulation of the development of various organs. Proc Natl Acad Sci U S A113, 6071-6076.Highlighted by “Commentary” of Proc Natl Acad Sci U S A 113, 5774-5776 (2016)
7. Li, K., Yu, R., Fan, L.M., Wei, N., Chen, H.* and Deng, X.W.* (2016). DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis. Nat Commun7, 11868. Highlighted by “Spotlight” of Trends Plant Sci 21, 813-815 (2016)
8. Li, K., Gao, Z., He, H., Terzaghi, W., Fan, L.M., Deng, X.W.,* and Chen, H.* (2015). Arabidopsis DET1 represses photomorphogenesis in part by negatively regulating DELLA protein abundance in darkness. Mol Plant8, 622-630.
9.Dong, J., Tang, D., Gao, Z., Yu, R., Li, K., He, H., Terzaghi, W., Deng, X.W., and Chen, H.* (2014). Arabidopsis DE-ETIOLATED1 represses photomorphogenesis by positively regulating phytochrome-interacting factors in the dark. Plant Cell26, 3630-3645.
10.Chen, H. ，# Xie, W., # He, H., # Yu, H., # Chen, W., Li, J., Yu, R., Yao, Y., Zhang, W., He, Y., Tang, X., Zhou, F., Deng, X.W., and Zhang, Q. (2014). A high-density SNP genotyping array for rice biology and molecular breeding. Mol Plant7, 541-553.
11.Chen, H.* He, H., Zhou, F., Yu, H., and Deng, X.W.* (2013). Development of genomics-based genotyping platforms and their applications in rice breeding. Curr Opin Plant Biol 16, 247-254.
12.Chen, H. # Huang, X.,# Gusmaroli, G., Terzaghi, W., Lau, O.S., Yanagawa, Y., Zhang, Y., Li, J., Lee, J.H., Zhu, D., and Deng, X.W. (2010). Arabidopsis CULLIN4-Damaged DNA Binding Protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell 22, 108-123.
13.Chen, H. Shen, Y., Tang, X., Yu, L., Wang, J., Guo, L., Zhang, Y., Zhang, H., Feng, S., Strickland, E., Zheng, N., and Deng, X.W. (2006). Arabidopsis CULLIN4 forms an E3 ubiquitin ligase with RBX1 and the CDD complex in mediating light control of development. Plant Cell 18, 1991-2004.
（# First author, * Corresponding author）
● 荣誉、奖励及参加学术团体的情况：
国家自然科学基金委优秀青年科学基金（2020）
Member of the international Molecular Moss Science Society (2016至今)
北京大学绿叶生物医药杰出青年学者奖（2016）
北京大学优秀博士后（2010）
北京大学优秀博士毕业生（2008）
● 联系方式：
邮箱： chenhaodong@tsinghua.edu.cn
电话：010-62790868（办公室）；010-62793033（实验室）
地址：公司生物技术馆3-112室（办公室）；3-105室，3-110室（实验室）
