王宏伟 博士

教授、博士生导师

1992-1996     公司生物科学与技术系，学士

1996-2001     公司生物科学与技术系，博士

2001-2006     美国劳伦斯伯克利国家实验室生命科学部，博士后

2006-2008     美国劳伦斯伯克利国家实验室生命科学部，研究科学家

2009-2011     美国耶鲁大学分子生物物理与生物化学系，Tenure-Track助理教授

2010.12-至今 澳门尼斯人娱乐网站(中国)有限公司，教授、博导

2016.04-2021.04   澳门尼斯人娱乐网站(中国)有限公司院长

●  研究兴趣、领域：

利用冷冻电子显微学研究生物大分子复合体的结构与分子机理。主要研究方向如下：

1. 更高效、更高分辨率的冷冻电镜方法学开发；

2. 核酸质量控制的分子机制和调控；

3. 细胞骨架和生物膜系统的协调机制。

●  代表性论文：

1. Chen J, Liu N, Huang Y, Wang Y, Sun Y, Wu Q, Li D, Gao S, Wang HW*, Huang N*, Qi X*, Wang XD*. (2021) Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nat. Commun., 12(1):6204.

2. Liu N, Zheng LM, Xu J, Wang J, Hu CX, Lan J, Zhang X, Zhang J, Xu K, Cheng H, Yang Z, Gao X, Wang X, Peng HL*, Chen YN*, Wang HW*. (2021) Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM. Biophysics Reports, 7(3): 227-238. (Cover)

3. Jin W, Wang J, Liu CP, Wang HW*, Xu RM*. (2020) Structural Basis for pri-miRNA Recognition by Drosha. Mol. Cell, 78(3): 423-439.

4. Fan X, Wang J, Zhang X, Yang Z, Zhang JC, Zhao L, Peng HL, Lei J*, Wang HW*. (2019) Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution. Nat. Commun., 10(1):2386.

5. Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW*, Zhou JM*, Chai J*. (2019) Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, 364(6435). pii: eaav5868.

6. Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW*, Zhou JM*, Chai J*. (2019) Reconstitution and structure of a plant NLR resistosome conferring immunity. Science, 364(6435). pii: eaav5870.

7. Liu N, Zhang J, Chen Y*, Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H*, Wang HW*. (2019) Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy. J. Am. Chem. Soc., 141(9):4016-4025.

8. Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang Q, Wang HW*. (2018) Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173(5):1191-1203.

9. Mei K, Li Y, Wang S, Shao G, Wang J, Ding Y, Luo G, Yue P, Liu JJ, Wang X, Dong MQ, Wang HW*, Guo W*. (2018) Cryo-EM structure of the exocyst complex. Nat. Struct. Mol. Biol., 25(2):139-146. (Cover)

10. Fan X, Zhao L, Liu C, Zhang JC, Fan K, Yan X, Peng HL, Lei J*, Wang HW*. (2017) Near-Atomic Resolution Structure Determination in Over-Focus with Volta Phase Plate by Cs-Corrected Cryo-EM. Structure, 25(10):1623-1630.

●  联系方式：

电话：+86-10-62772390 (office)

+86-10-62798651 (lab)

E-mail: hongweiwang@tsinghua.edu.cn

Lab website: http://cryoem.life.tsinghua.edu.cn/