Latest Research
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02 Apr
Liang Ge's group discovered a novel ag…
On April 1, 2022, Liang Ge's research group at the School of Life Sciences, Tsinghua University published a research article online in the journal "Cell" titled with “CCT2 is an aggrephagy receptor for clearance of solid protein aggregates”, discovered a novel aggrephagy receptor CCT2 and its important role in the clearance of solid protein aggregates.Aggrephagy is an important way to clear i...
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23 Jan
Xinquan Wang and collaborators reveal …
SARS-CoV-2 is responsible for the ongoing global COVID-19 pandemic, posing serious threat to public health. The exact origin and zoonotic transmission route of the SARS-CoV-2 are still unknown. The Spike (S) glycoprotein of coronaviruses mediates viral entry by binding host receptor and fusing viral and cellular membranes. And the molecular evolution of sequence and structures of spike affe...
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27 Dec
Wei Xie’s group published research on…
Prof. Wei Xie’s group at School of Life Science, Tsinghua University published research in Science Advances on December 22, 2021, entitled “Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs”. Their findings not only greatly deepen our fundamental understanding on how DNA methylation regulates early embryonic development in zebrafish, b...
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11 Jul
Zhucheng Chen’s group at Tsinghua Uni…
Recently, Professor Zhucheng Chen’s group at the School of Life Science reports the crystal structure of human ALC1 (amplification in liver cancer 1，also known as CHD1L：chromodomain helicase/ATPase DNA binding protein 1-like) and the cryo-EM structure bound to the nucleosome. In combination with biochemical analyses, their findings shed light on the regulation mechanisms of the enzyme, pavin...
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09 Jul
A new study elucidates an important me…
In a paper published online in the PLOS Biology on July 6, 2021, Jun Yao and coauthors of Tsinghua University reported their findings in the mechanism involving the deficits of Synaptotagmin-7-mediated activation of spontaneous NMDAR currents in bipolar disorder (BD), which is a complex neuropsychiatric disorder characterized by intermittent episodes of mania and depression.Neurotransmitter rel...
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30 Jun
Researchers discovered a Golgi-derived…
The endosome has highly dynamic motility and frequently undergoes fission and fusion events to coordinate endocytic trafficking. Endosome fission has been reported to be associated with cargo sorting. After internalization, cargoes can be segregated into distinct domains allocated for their destination, proceeding to either lysosomes for degradation, or the plasma membrane or trans-Golgi networ...
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03 Jun
Mitocytosis, a migrasome-mediated mito…
As vital organelles for eukaryotic cells, mitochondria are subject to tight quality control. Various mechanisms, including mitochondrial proteases, proteasome-mediated degradation of outer mitochondrial membrane (OMM) proteins, degradation of mitochondrial-derived vesicles (MDVs), and mitophagy have been shown play important roles in mitochondrial quality control.On 27th May of 2021, Professor ...
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19 Mar
Jijie Chai and collaborators publish …
Higher organisms have evolved the sophisticated immune system in their long-term competition with pathogenic microorganisms. The immune systems can be divided into two parts: innate immunity and adaptive immunity. The former, which is a universal and ancient form of host defense mechanism, can be initiated through perception of pathogens by a series of germline-encoded pattern recognition recep...
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01 Mar
Viral RNA structure data can be harne…
The SARS-CoV-2 virus is the causal pathogen for the worldwide COVID-19 pandemic (Perlman, 2020). To date, SARS-CoV-2 has infected more than 100 million people with more than 2.5 million deaths, causing tremendous damage to the global human society. SARS-CoV-2 is a single-stranded RNA virus, and its viral RNA is a key component in regulating host infection: the tiny SARS-CoV-2 genome (and the li...
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06 Feb
Yi Zhong’s group discovered the role …
Memory forms when a previously neutral stimulus (CS+) becomes competent to predict a biologically potent stimulus (US). But if the CS+ is repeatedly presented without the US after the memory formation, this memory will be suppressed by newly formed extinction memory. Extinction learning-induced suppression of memory has recently attracted major efforts for the development of psychiatric disorde...