Representative Papers of School of Life Science

• Structural basis of energy transfer in Porphyridium purpureum phycobilisome.

  Jianfei Ma#, Xin You#, Shan Sun#, Xiaoxiao Wang, Song Qin, Sen-Fang Sui*.

  NATURE 2020, 579(7797): 146–151.

• Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.

  Jun Lan#, Jiwan Ge#, Jinfang Yu#, Sisi Shan#, Huan Zhou, Shilong Fan, Qi Zhang, Xuanling Shi, Qisheng Wang, Linqi Zhang*, Xinquan Wang*.

  NATURE 2020, 581(7807): 215–220.

• A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

  Min Zhang#, Lei Liu#, Xubo Lin, Yang Wang, Ying Li, Qing Guo, Shulin Li, Yuxin Sun, Xuan Tao, Di Zhang, Xiachen Lv, Li Zheng, Liang Ge*.

  CELL 2020, 181 (3): 637-652.

• The landscape of RNA Pol II binding reveals a stepwise transition during ZGA.

  Bofeng Liu#, Qianhua Xu#, Qiujun Wang#, Su Feng, Fangnong Lai, Peizhe Wang, Fangyuan Zheng, Yunlong Xiang, Jingyi Wu, Junwei Nie, Cui Qiu, Weikun Xia, Lijia Li, Guang Yu, Zili Lin, Kai Xu, Zhuqing Xiong, Feng Kong, Ling Liu, Chunyi Huang, Yang Yu, Jie Na, Wei Xie*.

  NATURE 2020, 587(7832): 139–144.

• Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.

  Shoucai Ma#, Dmitry Lapin#, Li Liu#, Yue Sun#, Wen Song#, Xiaoxiao Zhang, Elke Logemann, Dongli Yu, Jia Wang, Jan Jirschitzka, Zhifu Han, Paul Schulze-Lefert*, Jane E. Parker*, Jijie Chai*.

  SCIENCE 2020, 370 (6521): eabe3069.

• Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.

  Nan Wang#, Xin Jiang#*, Shuo Zhang, Angqi Zhu, Yafei Yuan, Hanwen Xu, Jianlin Lei, Chuangye Yan*.

  CELL 2020, 184 (2): 370-383.

• Structures of the catalytically activated yeast spliceosome reveal the mechanism of branching.

  Wan, Ruixue; Bai, Rui; Yan, Chuangye; Lei, Jianlin; Shi, Yigong.

  CELL 2019, 177 (2): 339-351.

• Structural basis of Notch recognition by human γ-secretase.

  Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei, Yigong Shi.

  NATURE 2019,565 (7738): 192–197.

• P53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis.

  Li, Le; Mao, Youxiang; Zhao, Lina; Li, Lijia; Wu, Jinjun; Zhao, Mengjia; Du, Wenjing; Yu, Li; Jiang, Peng.

  NATURE 2019, 567 (7747): 253–256

• Mechanism of DNA translocation underlying chromatin remodelling by Snf2.

  Li, Meijing; Xia, Xian; Tian, Yuanyuan; Jia, Qi; Liu, Xiaoyu; Lu, Ying; Li, Ming; Li, Xueming; Chen, Zhucheng.

  NATURE 2019, 567 (7748): 409–413.

• Mechanisms of RALF peptide perception by a heterotypic receptor complex.

  Xiao, Yu; Stegmann, Martin; Han, Zhifu; DeFalco, Thomas A.; Parys, Katarzyna; Xu, Li; Belkhadir, Youssef; Zipfel, Cyril; Chai, Jijie.

  NATURE 2019, 572 (7768): 270–274.

• Recognition of the amyloid precursor protein by human gamma-secretase.

  Zhou, Rui; Yang, Guanghui; Guo, Xuefei; Zhou, Qiang; Lei, Jianlin; Shi, Yigong.

  SCIENCE 2019, 363 (6428): eaaw0930

• Reconstitution and structure of a plant NLR resistosome conferring immunity.

  Wang, Jizong; Hu, Meijuan; Wang, Jia; Qi, Jinfeng; Han, Zhifu; Wang, Guoxun; Qi, Yijun; Wang, Hong-Wei; Zhou, Jian-Min; Chai, Jijie.

  SCIENCE 2019, 364 (6435): eaav5870

• Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1

  Gu, Jinke; Zhang, Laixing; Zong, Shuai; Guo, Runyu; Liu, Tianya; Yi, Jingbo; Wang, Peiyi; Zhuo, Wei; Yang, Maojun.

  SCIENCE 2019, 364 (6445): 1068-1075.

• Resetting histone modifications during human parental-to-zygotic transition

  Xia, Weikun; Xu, Jiawei; Yu, Guang; Yao, Guidong; Xu, Kai; Ma, Xueshan; Zhang, Nan; Liu, Bofeng; Li, Tong; Lin, Zili; Chen, Xia; Li, Lijia; Wang, Qiujun; Shi, Dayuan; Shi, Senlin; Zhang, Yile; Song, Wenyan; Jin, Haixia; Hu, Linli; Bu, Zhiqin; Wang, Yang; Na, Jie; Xie, Wei; Sun, Ying-Pu.

  SCIENCE 2019, 365 (6451): 353-360.

• The pigment-protein network of a diatom photosystem II-light-harvesting antenna supercomplex

  Pi, Xiong; Zhao, Songhao; Wang, Wenda; Liu, Desheng; Xu, Caizhe; Han, Guangye; Kuang, Tingyun; Sui, Sen-Fang; Shen, Jian-Ren..

  SCIENCE 2019, 365 (6452): eaax4406.

• Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains.

  Huang, Yuwei; Zucker, Ben; Zhang, Shaojin; Elias, Sharon; Zhu, Yun; Chen, Hui; Ding, Tianlun; Li, Ying; Sun, Yujie; Lou, Jizhong; Kozlov, Michael M.; Yu, Li.

  NATURE CELL BIOLOGY 2019, 21 (8): 991-1002.

• Revealing lncRNA structures and interactions by sequencing-based approaches.

  Qian, Xingyang; Zhao, Jieyu; Yeung, Pui Yan; Zhang, Qiangfeng Cliff; Kwok, Chun Kit.

  TRENDS IN BIOCHEMICAL SCIENCES 2019, 44 (1): 33-52.

• Bioactive functionalized monolayer graphene for high-resolution Cryo-Electron Microscopy.

  Liu, Nan; Zhang, Jincan; Chen, Yanan; Liu, Chuan; Zhang, Xing; Xu, Kui; Wen, Jie; Luo, Zhipu; Chen, Shulin; Gao, Peng; Jia, Kaicheng; Liu, Zhongfan; Peng, Hailin; Wang, Hong-Wei.

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  2019, 141 (9): 4016-4025.

• Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism.

  Wang, Liang; Gao, Yifei; Zheng, Xiangdong; Liu, Cuifang; Dong, Shuangshuang; Li, Ru; Zhang, Guanwei; Wei, Yixuan; Qu, Hongyuan; Li, Yuhan; Allis, C. David; Li, Guohong; Li, Haitao; Li, Pilong.

  MOLECULAR CELL 2019, 76 (4): 646 -659.

• Mirror-image gene transcription and reverse transcription.

  Wang, Min; Jiang, Wenjun; Liu, Xianyu; Wang, Jiaxing; Zhang, Baochang; Fan, Chuyao; Liu, Lei; Pena-Alcantara, Giramnah; Ling, Jun-Jie; Chen, Ji; Zhu, Ting F.

  CHEM 2019, 5 (4): 848-857.