Zhen LI, Ph.D.

Professor


1988             Wuhan University                             B.S.

1995             Carnegie-Mellon University, USA                  Ph.D.

1995-1997    University of Michigan, USA               Postdoctor

1997-1999  Stanford University, USA                  Postdoctor

2000-2003    HKUST, Hong Kong                          Research Associate

2004-Present School of Life Sciences, Tsinghua University       Associate Professor, Professor

 

Research interest


Molecular mechanism of adiponectin

multimerization and secretion

Adiponectin-targeted drug development for Type 2 diabetes

 

Selected publications


1. Zhang YD, Wang YY, Li, XC, Gu, KR, Li MX, Zhang Y, Zhang ZJ, Wang SF, Li Z. 2020. WSF-7 inhibits obesity-mediated PPARgamma phosphorylation and improves insulin sensitivity in 3T3-L1 adipocytes. Biol Pharm Bull. 43(3):526-532.
2. Wang Y, Zhang Y, Wang Y, Peng H, Rui J, Zhang Z, Wang S, Li Z. 2017. WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes. Biosci Biotechnol Biochem. 81(8):1529-1535.
3. Liu LH, Xie JY, Guo WW, Wu GY, Chen ZF, Yi JY, Zhang L, Zhang ZJ, Li Z.2014. Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes. J Asian Nat Prod Res. 16(11):1074-83.
4. Wu G, Yi J, Liu L, Wang P, Zhang Z, Li Z. 2013. Pseudoginsenoside F11, a Novel Partial PPARγ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes. PPAR Res. Epub 2013 Dec 18.
5. Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. 2012. Promotion of adiponectin multimerization by emodin, a novel AMPK activator with PPARγ-agonist activity. J Cell Biochem. 113(11):3547-58.
6. Lin H, Li Y, Li Y, Yi J, Mai Y, Li Z. 2012. Tanshinone IIA promotes the assembly of adiponectin in 3T3-L1 adipocytes. Chin J of Nat Med. 10(2):150-154.
7. Lin H, Li Z. 2012. Adiponectin self-regulates its expression and multimerization in adipose tissue: an autocrine/paracrine mechanism? Med Hypotheses. 78(1):75-8.
8. Li Y, Wang P, Zhuang Y, Lin H, Li Y, Liu L, Meng Q, Cui T, Liu J, Li Z. 2011. Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes. FEBS Lett. 585(12):1735-40.

 

Contact information


TEL/FAX:+86-10-62770581

E-mail:lizhen@mail.tsinghua.edu.cn