Zhifu Han, Ph.D.

Research Associate Professor

1991.9－1996.7      Shanxi Medical University， Bachelor of Medicine.

1997.9－2000.7    Shanxi Medical University,  Master of Midicine

2000.9－2003.7     Peking Union Medical College, Ph.D.

2004.8－2010.12      National Institute of Biological Sciences, Beijing

2011.1－present     School of Life sciences, Tsinghua University

Research interest

Structural study of plant receptor-like kinases.

Selected publications

1            Song W, Liu L, Wang J, Wu Z, Zhang H, Tang J, Lin G, Wang Y, Wen X, Li W, Han Z*, Guo H*, Chai J*.Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell research 26, 674-685, (2016).

2            Song W*, Wang J*, Han Z*, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J, Wang HW, Chai J. Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nature structural & molecular biology 22, 782-787, (2015).

3            Han Z, Sun Y, Chai J.Structural insight into the activation of plant receptor kinases. Current opinion in plant biology 20, 55-63, (2014).

4            Sun Y, Li L, Macho AP, Han Z*, Hu Z, Zipfel C, Zhou JM*, Chai J*. Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science 342, 624-628, (2013).

5            Sun Y*, Han Z*, Tang J, Hu Z, Chai C, Zhou B, Chai J. Structure reveals that BAK1 as a co-receptor recognizes the BRI1-bound brassinolide. Cell research 23, 1326-1329, (2013).

6            Gao H, Wu X, Chai J, Han Z*.Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region. Cell research 22, 1716-1720, (2012).

7            She J*, Han Z*, Kim TW, Wang J, Cheng W, Chang J, Shi S, Wang J, Yang M, Wang ZY, Chai J.Structural insight into brassinosteroid perception by BRI1. Nature 474, 472-476, (2011).

8            Han Z*, Niu T*, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J.Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464, 1205-1209, (2010).

9            Han Z, Xing X, Hu M, Zhang Y, Liu P, Chai J. Structural basis of EZH2 recognition by EED. Structure 15, 1306-1315, (2007).

10          Han Z, Guo L, Wang H, Shen Y, Deng XW, Chai J. Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Molecular cell 22, 137-144, (2006).

Contact information

Email：hanzhifu@tsinghua.edu.cn