Yongzhang LUO     Ph.D.

Professor

1981-1985, B.S., Chemistry, Lanzhou University

1989-1993, Ph.D., Biochemistry, University of California at Berkeley

1993-1994, Postdoc, Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

1994-1998, Postdoc, Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA

Dr. Luo is currently a professor of Tsinghua University

Research interest

Luo’s laboratory seeks for molecular mechanisms and potential therapies of diseases from brand new perspectives based on the National Class I recombinant protein drug candidate. Research interests are listed below:

    Metabolic disease such as Type 2 diabetes mellitus, obesity etc.

    Degenerative disease such as Alzheimer's disease, Parkinson's disease etc.

Selected publications

1. Liu, H., Ju, A., Dong, X. et al. Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice. J Transl Med 21, 89 (2023). https://doi.org/10.1186/s12967-023-03957-3

2. Tang J, Ju A, Li B, et al. Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice. Biomolecules. 2021;11(8):1191. doi:10.3390/biom11081191

3. Liu W, Li J, Zhang P, et al. A novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic. Cancer Sci. 2019;110(9):2941-2959. doi:10.1111/cas.14143

4. Fu Y, Xu X, Huang D, et al. Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial. EBioMedicine. 2017;24:56-63. doi:10.1016/j.ebiom.2017.09.007

5. Wang H, Chen Y, Lu XA, Liu G, Fu Y, Luo Y. Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis. Diabetes. 2015;64(7):2442-2456. doi:10.2337/db14-0528

6. Wang X, Song X, Zhuo W, et al. The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy. Proc Natl Acad Sci U S A. 2009;106(50):21288-21293. doi:10.1073/pnas.0908151106

7. Huang Y, Song N, Ding Y, et al. Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis. Cancer Res. 2009;69(19):7529-7537. doi:10.1158/0008-5472.CAN-08-4382. “This landmark study demonstrated that ANGPT2-, MMP3- and MMP10-dependent pulmonary vascular destabilization is an early event occurring during the pre-metastatic phase, which promotes the extravasation of tumour cells and facilitates lung metastasis.” Cited and commented by Peinado, H., Zhang, H., Matei, I. et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer 17, 302–317 (2017). https://doi.org/10.1038/nrc.2017.6

8. Shi H, Huang Y, Zhou H, et al. Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin. Blood. (Featured in Cover) 2007;110(8):2899-2906. doi:10.1182/blood-2007-01-064428 Comment on Shi et al, page 2899, by Judah Folkman (2007). “Endostatin finds a new partner: nucleolin” Blood. 110, 2786-2787

Contact information

Tel：+86-10-62795106

Fax：+86-10-62794691

E-mail: protein@tsinghua.edu.cn