Zhi LU Ph.D.
Associate Professor
2017-present Bioinformatics and Genomics Associate Professor Tsinghua University, Beijing, China
2011-2016 Bioinformatics and Genomics Assistant Professor Tsinghua University, Beijing, China
2008-2011 Bioinformatics Postdoc Yale University, New Haven, CT, US
2003-2008 Biophysics Ph.D. University of Rochester, Rochester, NY, US
1998-2003 Life Sciences B.S. University of Science and Technology of China
Research interest
Our group is interested in developing bioinformatics technologies, and applying them in the genomic studies of animals and plants.
“Our mission is to detect cancer early, when it can be cured.” We utilize high-throughput sequencing technologies, together with machine learning and AI, to understand how genetic information is encoded in the structured DNA and RNA sequences, and how they interact and regulate each other in a biological system. Ultimately, this will help us understand and cure human diseases; know and improve ourselves.
The research in our lab include three directions:
1. RNA Regulation in animals and plants;
2. Precision Medicine;
3. Machine Learning and AI.
Selected publications
1. Shuaishuai Teng1, Yang Eric Li1, …, Zhi John Lu* and Dong Wang* (2020) Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer. Cell Research 30(1):34-49 (1contributed equally, *co-corresponding)
2. Yu-Xiang Chen1, Zhi-yu Xu1, Xueliang Ge, Suparna Sanyal, Zhi John Lu* and Babak Javid* (2020) Selective translation by alternative bacterial ribosomes. PNAS 117(32):19487-19496
3. Rui Xiao1, Jia-Yu Chen1, Zhengyu Liang1, Daji Luo, Geng Chen, Zhi John Lu, …, Michael Q. Zhang, Yu Zhou and Xiang-Dong Fu (2019) Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell 178, 107–121
4. Jiapei Yuan1, Jingrui Li1, Yang Yang, Chang Tan, Yumin Zhu, Long Hu, Yijun Qi* & Zhi John Lu* (2018) Stress-responsive regulation of long noncoding RNAs’ polyadenylation in Oryza sativa. The Plant Journal (1contributed equally) 93:5, 814-827
5. Yang Eric Li1, Mu Xiao1, Binbin Shi1, Yu-Cheng T. Yang, Dong Wang, Fei Wang, Marco Marcia and Zhi John Lu* (2017) Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA-protein binding sites. Genome Biology 18:169
6. Yang Yang1, Lei Chen1, Jin Gu1, Hanshuo Zhang1, …, Hongyang Wang*, Michael Q. Zhang* and Zhi John Lu* (2017) Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nature Communications 8, 14421
7. ENCODE Project Consortium#. (2012) An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature 489, 57–74. (#Lu Z was a member of ENCODE Consortium) [Cover Story] （cited > 17,000 )
8. Gerstein MB 1*, Lu ZJ1, Van Nostrand EL1, Cheng C1, Arshinoff BI1, et al. (2010) Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330(6012): 1775-1787 (120 co-first authors, *15 co-corresponding authors, ~150 authors in total) [Cover Story]
Contact information
Tel. /FAX: +86-10-62789217
E-mail: lulab1AT tsinghua.edu.cn
Lab page: http://lulab.life.tsinghua.edu.cn
MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China
