Haiteng DENG    Ph.D.

Professor

1996    Ph.D. degree, Department of Chemistry, Pennsylvania State University

1988    M.S. degree, Department of Chemistry, Wuhan University

1985    B.S. degree, Department of Chemistry, Wuhan University

 

5/1996-12/1997 Postdoctoral Fellow, Univ. of Alberta

1/1998-12/1999 Postdoctoral Associate, Oak Ridge National Laboratory

12/1999-12/2001 Instructor, Dept. of Developmental & Molecular Biology, Albert Einstein College of Medicine

12/2001-7/2003 Assistant Professor, Dept. of Medicine, Albert Einstein College of Medicine

8/2003-12/2003 Assistant Professor, University of Nebraska

1/2004-9/2009 Research Assistant Professor, Rockefeller University

9/2009-2/2011 Research Associate Professor and Director of Proteomics Resource Center, Rockefeller University

9/2008-Present Adjunct Faculty, New York University

3/2011-Present Adjunct Professor, Rockefeller University

3/2011-Professor（2017）, Tsinghua University, China

 

Research interest

Development of new techniques in proteomics, metabolomics, and chemical biology; Investigation of redox regulation in aging and associated diseases; Development of novel therapeutic and diagnostic approaches for aging associated diseases.

Selected publications

1. Wang W, Yang C, Wang T, Deng H., Complex roles of nicotinamide N-methyltransferase in cancer progression. Cell Death Dis. 2022 Mar 25;13(3):267.

2. Yang C, Zhu S, Chen Y, Liu Z, Zhang W, Zhao C, Luo C, Deng H.，Flavonoid 4,4'-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation. Free Radic Biol Med. 2021 Nov 1; 175:206-215.

3. Songbiao Zhu; Wenxi Ding; Yuling Chen; Weixuan Wang; Renhua Xu; Chongdong Liu; Xiaohui Liu; Haiteng Deng，High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumour Cells，Genomics, Proteomics & Bioinformatics，2021 Feb 26:S1672-0229.

4. Liu, Yan; Luo, Chengting; Li, Ting; Zhang, Wenhao; Zong, Zhaoyun; Liu, Xiaohui; Deng, Haiteng，Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Suppresses Glycolysis, TCA Cycle and Cell Growth，J Proteome Res. 2021 May 7;20(5):2596-2606.

5. Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H., Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages. Front Mol Biosci. 2021 Jul 6;8:702107.

7. Jin J, Meng X, Huo Y, Deng H., Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting. Cell Death Dis. 2021 Jul 13;12(7):697.

8. Zong Z, Liu J, Wang N, Yang C, Wang Q, Zhang W, Chen Y, Liu X, Deng H., Nicotinamide Mononucleotide Inhibits Hepatic Stellate Cell Activation to Prevent Liver Fibrosis via Promoting PGE2 Degradation., Free Radic Biol Med. 2021 Jan;162:571-581.

9. Meiqi Yi, Yingying Ma, Yuling Chen, Chongdong Liu, Qingtao Wang, and Haiteng Deng. Glutathionylation decreases methyltransferase activity of PRMT5 and inhibits cell proliferation. Mol Cell Proteomics. 2020 Nov;19(11):1910-1920.

10. Meiqi Yi, Yingying Ma, Songbiao Zhu, Chengting Luo, Yuling Chen, Qingtao Wang, Haiteng Deng. Comparative proteomic analysis identifies biomarkers for renal aging. Aging (Albany NY). 2020 Nov 6;12(21):21890-21903.

11. Zhang, Lin; Shen, Hao; Gong, Yiyi; Pang, Xiaojing; Yi, Meiqi; Guo, Lin; Li, Jin; Arroyo, Sam; Lu, Xin; Ovchinnikov, Sergey; Cheng, Gong; Liu, Xudong; Jiang, Xu; Feng, Shan; Deng, Haiteng; Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking, Chemical Science, 2019, 10(11): 3271-3280.

12. Teng, Ruifang; Liu, Zhilei; Tang, Haiping; Zhang, Wenhao; Chen, Yuling; Xu, Rrenhua; Chen, Liang; Song, Jiangping; Liu, Xiaohui; Deng, Haiteng; HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells, Redox Biology, 2019, 24: 101218.

13. Chen P, Wang H, Zhang W, Chen Y, Lv Y, Wu D, Guo M Sr, Deng H.，Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells. Molecular Cell Proteomics. 2019 Jul;18(7):1320-1329.

14. Wang, Weixuan; Hu, Yadong; Wang, Xiaofei; Wang, Qingtao; Deng, Haiteng*; ROS-mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition, Cell Chemical Biology, 2018, 25: 1-7.

15. Wang, Weixuan; Hu, Yadong; Yang, Changmei; Zhu, Songbiao; Wang, Xiaofei; Zhang, Zhenyu; Deng, Haiteng*; Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition, Molecular Cell Proteomics, 2018, 17(10): 2005-2017.

Chapters of Books:
1.J-R Zhang, MG Marinus, H Deng, Methylation and other Modifications of Nucleic Acids and Proteins, Reference Module in Biomedical Sciences, 2015 Elsevier Inc.
2.Amanda Chen, Haiqiang Yu, Haiteng Deng and W. Beau Mitchell, Mechanisms of αIIbβ3 Biogenesis in the Megakaryocyte: A Proteomics Approach in Hematology - Science and Practice, Edited by Charles H. Lawrie, ISBN 978-953-51-0174-1, Publisher: InTech, March 02, 2012 DOI: 10.5772/2259.
3.Haiteng Deng, Proteomics in Drug Discovery in Handbook of Drug Screening, R. Seethala, Eds, Informa Healthcare, May 2009.
4.Denis L. Rousseau, David Li, Eric Y. Hayden, Haiteng Deng and Syun-Ru Yeh, Protein-ligand interactions in mammalian nitric oxide synthase, in THE SMALLEST BIOMOLECULES: DIATOMICS AND THEIR INTERACTIONS WITH HEME PROTEINS, Abhik Ghosh, Eds, Elsevier, Dec 2007.

 

Contact information

Add: School of Life Sciences, Tsinghua University, Haidian District, Beijing, China (100084)

Tel: 010-62789415

E-mail: dht@mail.tsinghua.edu.cn